Prolonged adenovirus-mediated expression of p27(Kip1) unveils unexpected effects of this protein on the phenotype of SUDHL-1 cells derived from t(2;5)-anaplastic large cell lymphoma.

Abstract excerpt

SUDHL-1 cells, derived from human t(2;5)-anaplastic large cell lymphoma (ALCL) were kept in culture for 25 days and analyzed for p27(Kip1)-expression, cell cycle, apoptosis, morphology and phenotype as compared with matched controls at different time points after infection with recombinant adenovirus expressing p27(Kip1) (Adp27). The presence of any change in the cell phenotype occurring during the persistent...

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