Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms.

Molecular biology of the cell - 1 Feb 2000

Levy L, Broad S, Diekmann D, Evans R D, Watt F M

Abstract excerpt

In keratinocytes, the beta1 integrins mediate adhesion to the extracellular matrix and also regulate the initiation of terminal differentiation. To explore the relationship between these functions, we stably infected primary human epidermal keratinocytes and an undifferentiated squamous cell carcinoma line, SCC4, with retroviruses encoding wild-type and mutant chick beta1 integrin subunits. We examined the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Avian Sarcoma Viruses
Share to Cell Adhesion
Share to Chick Embryo

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Extracellular Matrix Proteins

Share to Fluorescent Antibody Technique

Share to Integrin beta1

Share to Keratinocytes

Share to Protein Precursors

Source

Open in PubMed Open full text

Identifiers

PMID: 10679006
DOI: 10.1091/mbc.11.2.453
PMCID: PMC14785

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

beta1 integrins regulate keratinocyte adhesion and differentiation by distinct mechanisms.PMID 10679006Read ↗

Different Consequences of β1 Integrin Deletion in Neonatal and Adult Mouse Epidermis Reveal a Context-Dependent Role of Integrins in Regulating Proliferation, Differentiation, and Intercellular CommunicationSemantic proximity Read ↗

A tumor-associated β1 integrin mutation that abrogates epithelial differentiation controlSemantic proximity Read ↗

Expression and function of the keratinocyte integrinsSemantic proximity Read ↗

Cellular integrins function as entry receptors for human cytomegalovirus via a highly conserved disintegrin-like domainSemantic proximity Read ↗

IntegrinsSemantic proximity Read ↗

Transforming growth factor-beta 1 modulates beta 1 and beta 5 integrin receptors and induces the de novo expression of the alpha v beta 6 heterodimer in normal human keratinocytes: implications for wound healing.Semantic proximity Read ↗

Keratinocytes display normal proliferation, survival and differentiation in conditional beta4-integrin knockout mice.Semantic proximity Read ↗

β1 integrins with individually disrupted cytoplasmic NPxY motifs are embryonic lethal but partially active in the epidermis.Semantic proximity Read ↗

Functional Re-expression of laminin-5 in laminin-gamma2-deficient human keratinocytes modifies cell morphology, motility, and adhesion.Semantic proximity Read ↗

beta1B integrin subunit contains a double lysine motif that can cause accumulation within the endoplasmic reticulum.Semantic proximity Read ↗

Functions of Pulmonary Epithelial Integrins: From Development to DiseaseSemantic proximity Read ↗

Outside-in Signaling through Integrins and Cadherins: A Central Mechanism to Control Epidermal Growth and Differentiation?Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.