Article
Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells.
FEBS letters - 18 Jul 2005
Zhang Qingxiu, Tian Ling, Mansouri Abdel, Korapati Anita L, Johnson Terry J, Claret Francois X
Abstract excerpt
The cyclin-dependent kinase (CDK) inhibitor p27(Kip1) (p27) is an important regulator of cell cycle progression controlling the transition from G to S-phase. Low p27 levels or accelerated p27 degradation correlate with excessive cell proliferation and poor prognosis in several forms of cancer. Phosphorylation of p27 at Thr187 by cyclin E-CDK2 is required to initiate the ubiquitination-proteasomal degradation of...
Topics
- Adenoviridae
- Alanine
- Annexin A5
- Apoptosis
- Biomarkers, Tumor
- Breast Neoplasms
- CDC2-CDC28 Kinases
- Cell Cycle
- Cell Cycle Proteins
- Cell Line
- Cell Line, Tumor
- Cell Proliferation
- Cyclin D1
- Cyclin E