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Article

Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells.

FEBS letters - 18 Jul 2005

Zhang Qingxiu, Tian Ling, Mansouri Abdel, Korapati Anita L, Johnson Terry J, Claret Francois X

Abstract excerpt

The cyclin-dependent kinase (CDK) inhibitor p27(Kip1) (p27) is an important regulator of cell cycle progression controlling the transition from G to S-phase. Low p27 levels or accelerated p27 degradation correlate with excessive cell proliferation and poor prognosis in several forms of cancer. Phosphorylation of p27 at Thr187 by cyclin E-CDK2 is required to initiate the ubiquitination-proteasomal degradation of...

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Identifiers

PMID: 15996662
DOI: 10.1016/j.febslet.2005.06.012
PMCID: PMC1366489

Genes

CDK2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Research trail→

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Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells.PMID 15996662Read ↗

p27kip1: a target for tumor therapies?Semantic proximity Read ↗

Caspase-induced proteolysis of the cyclin-dependent kinase inhibitor p27Kip1 mediates its anti-apoptotic activity.Semantic proximity Read ↗

Blockade of Protein Geranylgeranylation Inhibits Cdk2-Dependent p27<sup>Kip1</sup> Phosphorylation on Thr187 and Accumulates p27<sup>Kip1</sup> in the Nucleus: Implications for Breast Cancer TherapySemantic proximity Read ↗

Regulation of the Cdk inhibitor p27 and its deregulation in cancerSemantic proximity Read ↗

Deregulation of p27 by oncogenic signaling and its prognostic significance in breast cancerSemantic proximity Read ↗

Adenovirus expressing mutant p27kip1 enhanced apoptosis and inhibited the growth of xenografted human breast cancer.Semantic proximity Read ↗

Transfection of p27(Kip1) threonine residue 187 mutant type gene, which is not influenced by ubiquitin-mediated degradation, induces cell cycle arrest in oral squamous cell carcinoma cells.Semantic proximity Read ↗

Mislocalization of p27 to the cytoplasm of breast cancer cells confers resistance to anti-HER2 targeted therapySemantic proximity Read ↗

Regulation of the Cdk inhibitor p27 and its deregulation in cancerSemantic proximity Read ↗

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Brca1 inactivation induces p27(Kip1)-dependent cell cycle arrest and delayed development in the mouse mammary gland.Semantic proximity Read ↗

Mutations of phosphorylation sites Ser10 and Thr187 of p27Kip1 abolish cytoplasmic redistribution but do not abrogate G0/1 phase arrest in the HepG2 cell line.Semantic proximity Read ↗

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