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Article

αV integrin promotes <i>in vitro</i> and <i>in vivo</i> survival of cells in metastatic melanoma

2 Jun 2004

Abstract excerpt

The expression of integrin alphaV subunit on 4 melanoma-derived cell lines (A2058, SK-mel-5, WM-115 and WM-266-4) was analyzed. WM-115 cells, which originate from a primary tumor, were negative, whereas all 3 metastasis-derived lines had high levels of alphaV. To study alphaV integrins in the survival of melanoma cells, we developed a novel strategy that is exempt from extracellular inhibitors of ligand binding,...

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PMID: 15305376
DOI: 10.1002/ijc.20377

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