Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Adenovirus expressing mutant p27kip1 enhanced apoptosis and inhibited the growth of xenografted human breast cancer.

Surgery today - 1 Jan 2007

Sasaki Tsuyoshi, Katayose Yu, Yamamoto Kuniharu, Mizuma Masamichi, Shiraso Satoru, Yabuuchi Shinichi, Oda Akira, Rikiyama Toshiki, Oikawa Masaya, Onogawa Toru, Suzuki Masanori, Lee Choon-Taek, Unno Michiaki

Abstract excerpt

PURPOSE: To evaluate the anti-tumor effects of a novel adenovirus expressing mutant p27(kip1) (Adp27-mt), which consists of a mutation of Thr-187/Pro-188 to Met-187/Ile-188. METHODS: Using the human breast cancer cell lines, MDA-MB-231, ZR-75-1, and MCF-7, we tested Adp27-mt for cell cycle assay, growth inhibition assay, and TdT-mediated dUTP-biotin nick end labeling in a human breast cancer-grafted severe...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenoviridae
Share to Cyclin-Dependent Kinase Inhibitor p27

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Genetic Vectors

Share to Immunoprecipitation

Share to In Situ Nick-End Labeling

Share to Mice, SCID

Share to Neoplasm Transplantation

Share to Neoplasms, Experimental

Source

Identifiers

PMID: 18030569
DOI: 10.1007/s00595-007-3546-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Adenovirus expressing mutant p27kip1 enhanced apoptosis and inhibited the growth of xenografted human breast cancer.PMID 18030569Read ↗

Antitumor bioactivity of adenovirus-mediated p27mt in colorectal cancer cell line SW480.Semantic proximity Read ↗

A recombinant adenovirus expressing p27Kip1 induces cell cycle arrest and loss of cyclin-Cdk activity in human breast cancer cellsSemantic proximity Read ↗

Inducible expression of a degradation-resistant form of p27Kip1 causes growth arrest and apoptosis in breast cancer cells.Semantic proximity Read ↗

Advances in adenovirus-mediated p53 cancer gene therapySemantic proximity Read ↗

E1A- and E1B-Double mutant replicating adenovirus elicits enhanced oncolytic and antitumor effects.Semantic proximity Read ↗

High level expression of p27 <sup>kip1</sup> and cyclin D1 in some human breast cancer cells: Inverse correlation between the expression of p27 <sup>kip1</sup> and degree of malignancy in human breast and colorectal cancersSemantic proximity Read ↗

Prognostic role of p27Kip1 and apoptosis in human breast cancer.Semantic proximity Read ↗

Incorporating the survivin promoter in an infectivity enhanced CRAd-analysis of oncolysis and anti-tumor effects in vitro and in vivo.Semantic proximity Read ↗

Prolonged adenovirus-mediated expression of p27(Kip1) unveils unexpected effects of this protein on the phenotype of SUDHL-1 cells derived from t(2;5)-anaplastic large cell lymphoma.Semantic proximity Read ↗

Mutant p27(Kip1) and its potential effect as hepatocellular gene therapy.Semantic proximity Read ↗

The tumor suppressor activity induced by adenovirus-mediated BRCA1 overexpression is not restricted to breast cancers.Semantic proximity Read ↗

Effect of mutant p27(kipl) gene on human cholangiocarcinoma cell line, QBC(939).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.