Article
Expression of cyclin-dependent kinase inhibitor p27(Kip1) in AIDS-related diffuse large-cell lymphomas is associated with Epstein-Barr virus-encoded latent membrane protein 1.
The American journal of pathology - 1 Jul 2002
Gloghini Annunziata, Gaidano Gianluca, Larocca Luigi M, Pierconti Francesco, Cingolani Antonella, Dal Maso Luigino, Capello Daniela, Franceschi Silvia, Tirelli Umberto, Libra Massimo, Niu Huifeng, Dalla-Favera Riccardo, Carbone Antonino
Abstract excerpt
Knowledge of the role of cell-cycle regulators in the pathogenesis of acquired immune deficiency syndrome-related non-Hodgkin's lymphomas (AIDS-NHLs) is scarce. Here we analyzed 86 systemic AIDS-NHLs and 20 AIDS-primary central nervous system lymphomas for expression of p27(Kip1), a negative regulator of cell-cycle progression belonging to the Kip family of cyclin-dependent kinase inhibitors. In parallel, we...
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