Article
Effects of adenoviral wild-type p53 gene transfer in p53-mutated lymphoma cells.
Cancer gene therapy - 1 Jun 2001
Buttgereit P, Schakowski F, Märten A, Brand K, Renoth S, Ziske C, Schöttker B, Ebert O, Schroers R, Schmidt-Wolf I G
Abstract excerpt
The present study assessed the role of adenoviral vector-mediated wild-type p53 gene transfer in B lymphoma cells. Deficiency of p53-mediated cell death is common in human cancer contributing to both tumorigenesis and chemoresistance. Lymphoma cells are being considered as suitable targets for gene therapy protocols. Recently, we reported an adenoviral protocol leading to highly efficient gene transfer to B...
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