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Article

Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2.

Oncogene - 9 Jan 2003

Wong Johnson M S, Ionescu Daniela, Ingles C James

Abstract excerpt

Mutations in the BRCA1 and BRCA2 genes predispose women to familial, early-onset breast cancer. Both the BRCA1 and BRCA2 proteins appear to function in the homologous recombination pathway of DNA double-strand break repair. Both BRCA1 and BRCA2 have also been implicated in transcription by RNA polymerase II, for both proteins have domains which, when tethered adjacent to a promoter, can activate transcription. In...

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Source

Identifiers

PMID: 12527904
DOI: 10.1038/sj.onc.1206071

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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