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A Functional Interaction between the Human Papillomavirus 16 Transcription/Replication Factor E2 and the DNA Damage Response Protein TopBP1

1 Jun 2002

Abstract excerpt

The human papillomavirus (HPV) transcription/replication factor E2 is essential for the life cycle of HPVs. E2 protein binds to DNA target sequences in the viral long control regions to regulate transcription of the viral genome. It also enhances viral DNA replication by interacting with the viral replication factor E1 and recruiting it to the origin of replication and may also play a more direct role in...

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PMID: 11934899
DOI: 10.1074/jbc.m202163200

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A Functional Interaction between the Human Papillomavirus 16 Transcription/Replication Factor E2 and the DNA Damage Response Protein TopBP1PMID 11934899Read ↗

An Interaction between Human Papillomavirus 16 E2 and TopBP1 Is Required for Optimum Viral DNA Replication and Episomal Genome EstablishmentSemantic proximity Read ↗

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The Deacetylase SIRT1 Regulates the Replication Properties of Human Papillomavirus 16 E1 and E2Semantic proximity Read ↗

Human papillomavirus 16 E2 interaction with TopBP1 is required for E2 and viral genome stability during the viral life cycleSemantic proximity Read ↗

Why Human Papillomaviruses Activate the DNA Damage Response (DDR) and How Cellular and Viral Replication Persists in the Presence of DDR SignalingSemantic proximity Read ↗

Direct interaction with the BRD4 carboxyl-terminal motif (CTM) and TopBP1 is required for human papillomavirus 16 E2 association with mitotic chromatin and plasmid segregation functionSemantic proximity Read ↗

E2 displacement of CIP2A from TOPBP1 activates the DNA damage response during papillomavirus life cyclesSemantic proximity Read ↗

TopBP1 Regulates Human Papillomavirus Type 16 E2 Interaction with ChromatinSemantic proximity Read ↗

Mechanisms of Viral DNA Replication of Human Papillomavirus: E2 Protein-Dependent Recruitment of E1 DNA Helicase to the Origin of DNA ReplicationSemantic proximity Read ↗

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