Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A protective role for BRCA2 at stalled replication forks.

Breast cancer research : BCR - 7 Sept 2011

Chandramouly Gurushankar, Willis Nicholas A, Scully Ralph

Abstract excerpt

The hereditary breast and ovarian cancer predisposition genes BRCA1 and BRCA2 account for the lion's share of heritable breast cancer risk in the human population. Loss of function of either gene results in defective homologous recombination (HR) and triggers genomic instability, accelerating bre...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA1 Protein
Share to BRCA2 Protein
Share to Breast Neoplasms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to DNA Replication

Share to Genomic Instability

Share to Homologous Recombination

Share to Hydroxyurea

Share to Mutation

Source

Open in PubMed Open full text

Identifiers

PMID: 21996371
DOI: 10.1186/bcr2918
PMCID: PMC3262192

Genes

BRCA2
BRCA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-21996371-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A protective role for BRCA2 at stalled replication forks.PMID 21996371Read ↗

Guardians of the Genome: BRCA2 and Its Partners.Semantic proximity Read ↗

Mechanisms underlying genome maintenance and tumour suppression by BRCA2Semantic proximity Read ↗

BRCA1 and BRCA2: breast/ovarian cancer susceptibility gene products and participants in DNA double-strand break repair.Semantic proximity Read ↗

Tumour suppressor mechanisms in the control of chromosome stability: insights from BRCA2.Semantic proximity Read ↗

DNA recombination, chromosomal stability and carcinogenesis: insights into the role of BRCA2.Semantic proximity Read ↗

The roles of BRCA1 and BRCA2 and associated proteins in the maintenance of genomic stability.Semantic proximity Read ↗

The Breast Cancer Susceptibility Gene BRCA2 Is Required for the Maintenance of Telomere HomeostasisSemantic proximity Read ↗

Homology-Directed Repair and the Role of BRCA1, BRCA2, and Related Proteins in Genome Integrity and CancerSemantic proximity Read ↗

In brief: BRCA1 and BRCA2.Semantic proximity Read ↗

BRCA1 and BRCA2 in breast cancer predisposition and recombination control.Semantic proximity Read ↗

Homologous repair of DNA damage and tumorigenesis: the BRCA connection.Semantic proximity Read ↗

Cancer susceptibility and the functions of BRCA1 and BRCA2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.