Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Bimodal interaction between replication-protein A and Dna2 is critical for Dna2 function both in vivo and in vitro.

Nucleic acids research - 15 Jun 2003

Bae Kwang-Hee, Kim Hee-Sook, Bae Sung-Ho, Kang Ho-Young, Brill Steven, Seo Yeon-Soo

Abstract excerpt

We have previously shown that replication- protein A (RPA), the heterotrimeric single-stranded DNA binding protein of eukaryotes, plays a role in Okazaki fragment processing by acting as a molecular switch between the two endonucleases, Dna2 and Fen1, to ensure the complete removal of primer RNAs in Saccharomyces cerevisiae. The stimulation of Dna2 endonuclease activity by RPA requires direct protein-protein...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to DNA Helicases

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Endonucleases

Share to Genes, Lethal

Share to Protein Subunits

Share to Replication Protein A

Share to Saccharomyces cerevisiae Proteins

Share to Suppression, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 12799426
DOI: 10.1093/nar/gkg422
PMCID: PMC162255

Genes

DNA2
RPA1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Bimodal interaction between replication-protein A and Dna2 is critical for Dna2 function both in vivo and in vitro.PMID 12799426Read ↗

Replication Protein A, the Main Eukaryotic Single-Stranded DNA Binding Protein, a Focal Point in Cellular DNA MetabolismSemantic proximity Read ↗

Characterization of genetic interactions with RFA1: the role of RPA in DNA replication and telomere maintenance.Semantic proximity Read ↗

Genetic analysis of the Replication Protein A large subunit family in Arabidopsis reveals unique and overlapping roles in DNA repair, meiosis and DNA replication.Semantic proximity Read ↗

Analysis of the human replication protein A:Rad52 complex: evidence for crosstalk between RPA32, RPA70, Rad52 and DNA.Semantic proximity Read ↗

Essential functions of the 32 kDa subunit of yeast replication protein A.Semantic proximity Read ↗

Functional analysis of the four DNA binding domains of replication protein A. The role of RPA2 in ssDNA binding.Semantic proximity Read ↗

Dissection of functional domains of the human DNA replication protein complex replication protein A.Semantic proximity Read ↗

A novel allele of fission yeast rad11 that causes defects in DNA repair and telomere length regulation.Semantic proximity Read ↗

Replication protein A (RPA1a) is required for meiotic and somatic DNA repair but is dispensable for DNA replication and homologous recombination in rice.Semantic proximity Read ↗

Replication protein A: single-stranded DNA's first responder: dynamic DNA-interactions allow replication protein A to direct single-strand DNA intermediates into different pathways for synthesis or repair.Semantic proximity Read ↗

A yeast replicative helicase, Dna2 helicase, interacts with yeast FEN-1 nuclease in carrying out its essential function.Semantic proximity Read ↗

The transcription elongation factor Bur1-Bur2 interacts with replication protein A and maintains genome stability during replication stress.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.