Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The BRCA2 activation domain associates with and is phosphorylated by a cellular protein kinase.

Oncogene - 7 Sept 2000

Milner J, Fuks F, Hughes-Davies L, Kouzarides T

Abstract excerpt

A substantial proportion of familial breast cancers have mutations within the BRCA2 gene. The product of this gene has been implicated in DNA repair and in the regulation of transcription. We have previously identified at the amino-terminus of BRCA2 a transcriptional activation domain whose importance is highlighted by the presence of predisposing mutations and in-frame deletions in breast cancer families. This...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to BRCA2 Protein
Share to Glutathione Transferase
Share to JNK Mitogen-Activated Protein Kinases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mitogen-Activated Protein Kinase 8

Share to Mitogen-Activated Protein Kinases

Share to Precipitin Tests

Share to Protein Kinases

Share to Ultraviolet Rays

Source

Identifiers

PMID: 10980621
DOI: 10.1038/sj.onc.1203793

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The BRCA2 activation domain associates with and is phosphorylated by a cellular protein kinase.PMID 10980621Read ↗

Role of BRCA1 and BRCA2 as regulators of DNA repair, transcription, and cell cycle in response to DNA damage.Semantic proximity Read ↗

Identification of a specific domain responsible for JNK2alpha2 autophosphorylation.Semantic proximity Read ↗

Structure and expression of variant BRCA2a lacking the transactivation domain.Semantic proximity Read ↗

In vitro phosphorylation of BRCA2 by the checkpoint kinase CHEK2.Semantic proximity Read ↗

BRCA2 cooperates with histone acetyltransferases in androgen receptor-mediated transcription.Semantic proximity Read ↗

BRCA1 associates with human papillomavirus type 18 E2 and stimulates E2-dependent transcription.Semantic proximity Read ↗

Clues to the function of the tumour susceptibility gene BRCA2.Semantic proximity Read ↗

M phase-specific phosphorylation of BRCA2 by Polo-like kinase 1 correlates with the dissociation of the BRCA2-P/CAF complex.Semantic proximity Read ↗

New insights into the biological function of BRCA2 from its structural interactions.Semantic proximity Read ↗

Interaction between the product of the breast cancer susceptibility gene BRCA2 and DSS1, a protein functionally conserved from yeast to mammals.Semantic proximity Read ↗

Induction of the BRCA2 promoter by nuclear factor-kappa B.Semantic proximity Read ↗

Interaction between BRCA2 and replication protein A is compromised by a cancer-predisposing mutation in BRCA2.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.