Article
BRCA1, BRCA2, and Rad51 operate in a common DNA damage response pathway.
Cancer research - 1 Apr 1999
Chen J J, Silver D, Cantor S, Livingston D M, Scully R
Abstract excerpt
The two major hereditary breast cancer susceptibility genes, BRCA1 and BRCA2, are associated with early-onset breast and/or ovarian cancer and encode products that each interact with the product of the eukaryotic RecA homologue, hRad51. We have recently found that BRCA1 and BRCA2 coexist in a common biochemical complex. The two proteins also colocalize in subnuclear foci in somatic cells as well as on the axial...
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