Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions.

doi:10.1073/pnas.0600298103

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Article

Suppression of the DNA repair defects of BRCA2-deficient cells with heterologous protein fusions.

Proceedings of the National Academy of Sciences of the United States of America - 6 Jun 2006

Saeki Hiroshi, Siaud Nicolas, Christ Nicole, Wiegant Wouter W, van Buul Paul P W, Han Mingguang, Zdzienicka Malgorzata Z, Stark Jeremy M, Jasin Maria

Abstract excerpt

The BRCA2 tumor suppressor plays an important role in the repair of DNA damage by homologous recombination, also termed homology-directed repair (HDR). Human BRCA2 is 3,418 aa and is composed of several domains. The central part of the protein contains multiple copies of a motif that binds the Rad51 recombinase (the BRC repeat), and the C terminus contains domains that have structural similarity to domains in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 16731627
DOI: 10.1073/pnas.0600298103
PMCID: PMC1482653

Genes

BRCA2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.