Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of Neuronal Enhancers of the Proopiomelanocortin Gene by Transgenic Mouse Analysis and Phylogenetic Footprinting

29 Mar 2005

Abstract excerpt

The proopiomelanocortin (POMC) gene is expressed in the pituitary and arcuate neurons of the hypothalamus. POMC arcuate neurons play a central role in the control of energy homeostasis, and rare loss-of-function mutations in POMC cause obesity. Moreover, POMC is the prime candidate gene within a highly significant quantitative trait locus on chromosome 2 associated with obesity traits in several human...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adipose Tissue and Metabolism
Share to Biochemical Analysis and Sensing Techniques
Share to Regulation of Appetite and Obesity

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 15798195
DOI: 10.1128/mcb.25.8.3076-3086.2005

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of Neuronal Enhancers of the Proopiomelanocortin Gene by Transgenic Mouse Analysis and Phylogenetic FootprintingPMID 15798195Read ↗

Enhancer turnover and conserved regulatory function in vertebrate evolution.Semantic proximity Read ↗

Molecular and functional genetics of the proopiomelanocortin gene, food intake regulation and obesitySemantic proximity Read ↗

Defining POMC neurons using transgenic reagents: impact of transient Pomc expression in diverse immature neuronal populations.Semantic proximity Read ↗

A Pituitary-Specific Enhancer of the POMC Gene with Preferential Activity in Corticotrope CellsSemantic proximity Read ↗

Islet 1 specifies the identity of hypothalamic melanocortin neurons and is critical for normal food intake and adiposity in adulthoodSemantic proximity Read ↗

Comparative Transcriptomic Analyses of Developing Melanocortin Neurons Reveal New Regulators for the Anorexigenic Neuron IdentitySemantic proximity Read ↗

60 YEARS OF POMC: The proopiomelanocortin gene: discovery, deletion and disease.Semantic proximity Read ↗

Developmental dependence on NurRE and EboxNeuro for expression of pituitary proopiomelanocortin.Semantic proximity Read ↗

Expression of a hypomorphic Pomc allele alters leptin dynamics during late pregnancy.Semantic proximity Read ↗

Epigenetic regulation of POMC; implications for nutritional programming, obesity and metabolic diseaseSemantic proximity Read ↗

Developmental single-cell transcriptomics of hypothalamic POMC neurons reveal the genetic trajectories of multiple neuropeptidergic phenotypes.Semantic proximity Read ↗

60 YEARS OF POMC: Transcriptional and epigenetic regulation of POMC gene expressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.