Article
Molecular dissection of the eukaryotic initiation factor 4E (eIF4E) export-competent RNP.
The EMBO journal - 22 Apr 2009
Topisirovic Ivan, Siddiqui Nadeem, Lapointe Vincent Leroux, Trost Matthias, Thibault Pierre, Bangeranye Catherine, Piñol-Roma Serafin, Borden Katherine L B
Abstract excerpt
The eukaryotic translation initiation factor 4E (eIF4E) controls gene expression through its effects on mRNA export and cap-dependent translation, both of which contribute to its oncogenic potential. In contrast to its translation function, the mRNA export function of eIF4E is poorly understood. Using an RNP isolation/mass spectrometry approach, we identified candidate cofactors of eIF4E mRNA export including...
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