Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Nucleotide variability at G6pd and the signature of malarial selection in humans.

Genetics - 1 Dec 2002

Saunders Matthew A, Hammer Michael F, Nachman Michael W

Abstract excerpt

Glucose-6-phosphate dehydrogenase (G6PD) deficiency is the most common enzymopathy in humans. Deficiency alleles for this X-linked disorder are geographically correlated with historical patterns of malaria, and the most common deficiency allele in Africa (G6PD A-) has been shown to confer some resistance to malaria in both hemizygous males and heterozygous females. We studied DNA sequence variation in 5.1 kb of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chromosomes, Human, X
Share to Evolution, Molecular
Share to Genetic Linkage

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Glucosephosphate Dehydrogenase

Share to Glucosephosphate Dehydrogenase Deficiency

Share to Linkage Disequilibrium

Share to Malaria, Falciparum

Share to Selection, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 12524354
DOI: 10.1093/genetics/162.4.1849
PMCID: PMC1462360

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Nucleotide variability at G6pd and the signature of malarial selection in humans.PMID 12524354Read ↗

Haplotype diversity and linkage disequilibrium at human G6PD: recent origin of alleles that confer malarial resistance.Semantic proximity Read ↗

The extent of linkage disequilibrium caused by selection on G6PD in humans.Semantic proximity Read ↗

Contrasting histories of G6PD molecular evolution and malarial resistance in humans and chimpanzees.Semantic proximity Read ↗

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.Semantic proximity Read ↗

Epidemiology, evolutionary origin, and malaria-induced positive selection effects of G6PD-deficient alleles in Chinese populations.Semantic proximity Read ↗

Human genetic variations conferring resistance to malaria.Semantic proximity Read ↗

Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility.Semantic proximity Read ↗

Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria.Semantic proximity Read ↗

Polymorphic sites in the African population detected by sequence analysis of the glucose-6-phosphate dehydrogenase gene outline the evolution of the variants A and A-.Semantic proximity Read ↗

Reappraisal of known malaria resistance loci in a large multicenter study.Semantic proximity Read ↗

Three hallmarks of malaria-induced selection in human genomesSemantic proximity Read ↗

Human mutations in glucose 6-phosphate dehydrogenase reflect evolutionary history.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.