Article
Human mutations in glucose 6-phosphate dehydrogenase reflect evolutionary history.
FASEB journal : official publication of the Federation of American Societies for Experimental Biology - 1 Mar 2000
Notaro R, Afolayan A, Luzzatto L
Abstract excerpt
Glucose 6-phosphate dehydrogenase (G6PD) is a cytosolic enzyme encoded by a housekeeping X-linked gene whose main function is to produce NADPH, a key electron donor in the defense against oxidizing agents and in reductive biosynthetic reactions. Inherited G6PD deficiency is associated with either episodic hemolytic anemia (triggered by fava beans or other agents) or life-long hemolytic anemia. We show here that...
Topics
- Amino Acid Sequence
- Animals
- Evolution, Molecular
- Genetic Variation
- Glucosephosphate Dehydrogenase
- Humans
- Molecular Sequence Data
- Mutation
- Mutation, Missense
- Open Reading Frames
- Peptide Library