Article
Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria.
Nature - 20 Jul 1995
Ruwende C, Khoo S C, Snow R W, Yates S N, Kwiatkowski D, Gupta S, Warn P, Allsopp C E, Gilbert S C, Peschu N
Abstract excerpt
Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzymopathy of humans, affects over 400 million people. The geographical correlation of its distribution with the historical endemicity of malaria suggests that this disorder has risen in frequency through natural selection by m...
Topics
- Africa
- Alleles
- Base Sequence
- Case-Control Studies
- Child
- Child, Preschool
- DNA Primers
- Female
- Gene Frequency
- Genotype
- Glucosephosphate Dehydrogenase Deficiency
- Heterozygote
- Humans
- Immunity, Innate
- Infant
- Malaria
- Male
- Models, Biological