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Article

Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria.

Nature - 20 Jul 1995

Ruwende C, Khoo S C, Snow R W, Yates S N, Kwiatkowski D, Gupta S, Warn P, Allsopp C E, Gilbert S C, Peschu N

Abstract excerpt

Glucose-6-phosphate dehydrogenase (G6PD) deficiency, the most common enzymopathy of humans, affects over 400 million people. The geographical correlation of its distribution with the historical endemicity of malaria suggests that this disorder has risen in frequency through natural selection by malaria. However, attempts to confirm that G6PD deficiency is protective in case-control studies of malaria have yielded...

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PMID: 7617034
DOI: 10.1038/376246a0

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Related research

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Natural selection of hemi- and heterozygotes for G6PD deficiency in Africa by resistance to severe malaria.PMID 7617034Read ↗

X-linked G6PD deficiency protects hemizygous males but not heterozygous females against severe malaria.Semantic proximity Read ↗

African glucose-6-phosphate dehydrogenase alleles associated with protection from severe malaria in heterozygous females in Tanzania.Semantic proximity Read ↗

Characterisation of the opposing effects of G6PD deficiency on cerebral malaria and severe malarial anaemia.Semantic proximity Read ↗

Glucose-6-phosphate dehydrogenase deficiency and reduced haemoglobin levels in African children with severe malaria.Semantic proximity Read ↗

Genetic benefits of consanguinity through selection of genotypes protective against malaria.Semantic proximity Read ↗

Heterogeneous alleles comprising G6PD deficiency trait in West Africa exert contrasting effects on two major clinical presentations of severe malaria.Semantic proximity Read ↗

Nucleotide variability at G6pd and the signature of malarial selection in humans.Semantic proximity Read ↗

Allelic heterogeneity of G6PD deficiency in West Africa and severe malaria susceptibility.Semantic proximity Read ↗

Controlled Human Malaria Infection reveals that the Dantu blood group variant provides high level protection against uncomplicated malariaSemantic proximity Read ↗

The extent of linkage disequilibrium caused by selection on G6PD in humans.Semantic proximity Read ↗

Evidence of positively selected G6PD A- allele reduces risk of Plasmodium falciparum infection in African population on Bioko Island.Semantic proximity Read ↗

The impact of phenotypic and genotypic G6PD deficiency on risk of plasmodium vivax infection: a case-control study amongst Afghan refugees in Pakistan.Semantic proximity Read ↗

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