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Article

The evolution of isochores: evidence from SNP frequency distributions.

Genetics - 1 Dec 2002

Lercher Martin J, Smith Nick G C, Eyre-Walker Adam, Hurst Laurence D

Abstract excerpt

The large-scale systematic variation in nucleotide composition along mammalian and avian genomes has been a focus of the debate between neutralist and selectionist views of molecular evolution. Here we test whether the compositional variation is due to mutation bias using two new tests, which do not assume compositional equilibrium. In the first test we assume a standard population genetics model, but in the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 12524350
DOI: 10.1093/genetics/162.4.1805
PMCID: PMC1462390

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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