Fixation biases affecting human SNPs.

doi:10.1016/j.tig.2004.01.005

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Article

Fixation biases affecting human SNPs.

Trends in genetics : TIG - 1 Mar 2004

Webster Matthew T, Smith Nick G C

Abstract excerpt

Under neutrality all classes of mutation have an equal probability of becoming fixed in a population. In this article, we describe our analysis of the frequency distributions of >5000 human SNPs and provide evident of biases in the process of fixation of certain classes of point mutation that are most likely to be attributable to biased gene conversion. The results indicate an increased fixation probability of...

Topics

Alleles
Base Composition
Gene Frequency
Genome, Human
Humans
Models, Genetic
Mutation
Polymorphism, Single Nucleotide

Source

Open in PubMed

Identifiers

PMID: 15049304
DOI: 10.1016/j.tig.2004.01.005

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