Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Compositional evolution of noncoding DNA in the human and chimpanzee genomes.

Molecular biology and evolution - 1 Feb 2003

Webster Matthew T, Smith Nick G C, Ellegren Hans

Abstract excerpt

We have examined the compositional evolution of noncoding DNA in the primate genome by comparison of lineage-specific substitutions observed in 1.8 Mb of genomic alignments of human, chimpanzee, and baboon with 6542 human single-nucleotide polymorphisms (SNPs) rooted using chimpanzee sequence. The pattern of compositional evolution, measured in terms of the numbers of GC-->AT and AT-->GC changes, differs...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alleles
Share to Genome
Share to Genome, Human

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Likelihood Functions

Share to Models, Statistical

Share to Pan troglodytes

Share to Polymorphism, Single Nucleotide

Source

Identifiers

PMID: 12598695
DOI: 10.1093/molbev/msg037

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Compositional evolution of noncoding DNA in the human and chimpanzee genomes.PMID 12598695Read ↗

Context-dependent mutation rates may cause spurious signatures of a fixation bias favoring higher GC-content in humans.Semantic proximity Read ↗

Deterministic mutation rate variation in the human genome.Semantic proximity Read ↗

Genomewide comparison of DNA sequences between humans and chimpanzees.Semantic proximity Read ↗

Mutational spectrum in the recent human genome inferred by single nucleotide polymorphisms.Semantic proximity Read ↗

Vanishing GC-rich isochores in mammalian genomes.Semantic proximity Read ↗

A novel method distinguishes between mutation rates and fixation biases in patterns of single-nucleotide substitution.Semantic proximity Read ↗

Population dynamics of GC-changing mutations in humans and great apesSemantic proximity Read ↗

Context dependent substitution biases vary within the human genome.Semantic proximity Read ↗

Mutations of different molecular origins exhibit contrasting patterns of regional substitution rate variation.Semantic proximity Read ↗

Initial sequence of the chimpanzee genome and comparison with the human genome.Semantic proximity Read ↗

Non-B DNA: a major contributor to small- and large-scale variation in nucleotide substitution frequencies across the genome.Semantic proximity Read ↗

Hypermutable non-synonymous sites are under stronger negative selection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.