Article
Vanishing GC-rich isochores in mammalian genomes.
Genetics - 1 Dec 2002
Duret Laurent, Semon Marie, Piganeau Gwenaël, Mouchiroud Dominique, Galtier Nicolas
Abstract excerpt
To understand the origin and evolution of isochores-the peculiar spatial distribution of GC content within mammalian genomes-we analyzed the synonymous substitution pattern in coding sequences from closely related species in different mammalian orders. In primate and cetartiodactyls, GC-rich genes are undergoing a large excess of GC --> AT substitutions over AT --> GC substitutions: GC-rich isochores are slowly...
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