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Article

A novel method distinguishes between mutation rates and fixation biases in patterns of single-nucleotide substitution.

Journal of molecular evolution - 1 Feb 2006

Lipatov Mikhail, Arndt Peter F, Hwa Terence, Petrov Dmitri A

Abstract excerpt

Analysis of the genome-wide patterns of single-nucleotide substitution reveals that the human GC content structure is out of equilibrium. The substitutions are decreasing the overall GC content (GC), at the same time making its range narrower. Investigation of single-nucleotide polymorphisms (SNPs) revealed that presently the decrease in GC content is due to a uniform mutational preference for A:T pairs, while...

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Identifiers

PMID: 16362483
DOI: 10.1007/s00239-005-0207-z

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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