Recombination drives the evolution of GC-content in the human genome.

doi:10.1093/molbev/msh070

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Article

Recombination drives the evolution of GC-content in the human genome.

Molecular biology and evolution - 1 Jun 2004

Meunier Julien, Duret Laurent

Abstract excerpt

Unraveling the evolutionary forces responsible for variations of neutral substitution patterns among taxa or along genomes is a major issue in the identification of functional sequence features. Mammalian genomes show large-scale regional variations of GC-content (the isochores), but the substitution processes at the origin of this structure are poorly understood. We have analyzed the pattern of neutral...

Topics

Animals
Base Composition
Base Sequence
Computer Simulation
Databases, Nucleic Acid
Evolution, Molecular
Gene Conversion
Genome, Human
Humans
Mutation
Primates
Recombination, Genetic
Sequence Alignment

Source

Open in PubMed

Identifiers

PMID: 14963104
DOI: 10.1093/molbev/msh070

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