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Article

Evidence of selection on silent site base composition in mammals: potential implications for the evolution of isochores and junk DNA.

Genetics - 1 Jun 1999

Eyre-Walker A

Abstract excerpt

It has been suggested that mutation bias is the major determinant of base composition bias at synonymous, intron, and flanking DNA sites in mammals. Here I test this hypothesis using population genetic data from the major histocompatibility genes of several mammalian species. The results of two tests are inconsistent with the mutation hypothesis in coding, noncoding, CpG-island, and non-CpG-island DNA, but are...

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Identifiers

PMID: 10353909
DOI: 10.1093/genetics/152.2.675
PMCID: PMC1460637

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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