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Article

Both selective and neutral processes drive GC content evolution in the human genome.

BMC evolutionary biology - 27 Mar 2008

Pozzoli Uberto, Menozzi Giorgia, Fumagalli Matteo, Cereda Matteo, Comi Giacomo P, Cagliani Rachele, Bresolin Nereo, Sironi Manuela

Abstract excerpt

BACKGROUND: Mammalian genomes consist of regions differing in GC content, referred to as isochores or GC-content domains. The scientific debate is still open as to whether such compositional heterogeneity is a selected or neutral trait. RESULTS: Here we analyze SNP allele frequencies, retrotransposon insertion polymorphisms (RIPs), as well as fixed substitutions accumulated in the human lineage since its...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genome, Human

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Identifiers

PMID: 18371205
DOI: 10.1186/1471-2148-8-99
PMCID: PMC2292697

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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