Article
A new framework for studying the isochore evolution: estimation of the equilibrium GC content based on the temporal mutation rate model.
Genome biology and evolution - 1 Jan 2010
Oota Satoshi, Kawamura Kazuhiro, Kawai Yosuke, Saitou Naruya
Abstract excerpt
Isochore is the genome-wide mosaic structure in guanine-cytosine (GC) content. The origin of isochores is thought to have emerged in the ancestral amniote genome, and the GC-rich isochore is eroded in the mammalian lineages. However, there are many enigmas in the isochore evolution: 1) although all the mammalians, birds, and even reptiles, which are clearly polyphyletic, have isochore, opossum and platypus lack...
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