Article
Effects of hyperfibrinogenemia on vasculature of C57BL/6 mice with and without atherogenic diet.
Arteriosclerosis, thrombosis, and vascular biology - 1 Jan 2003
Gulledge Alyssa A, McShea Cynthia, Schwartz Todd, Koch Gary, Lord Susan T
Abstract excerpt
OBJECTIVE: Elevated fibrinogen is correlated with severe atherosclerosis, as defined by the occurrence of ischemic events, but the mechanistic basis for this correlation remains unknown. To study this relationship, we examined spontaneous and diet-induced atherosclerosis in transgenic mice with hyperfibrinogenemia (elevated fibrinogen). METHODS AND RESULTS: Normal and transgenic mice were fed either an...
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