Article
HDL deficiency in genetically engineered mice requires elevated LDL to accelerate atherogenesis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 1997
Hughes S D, Verstuyft J, Rubin E M
Abstract excerpt
In humans, a low HDL concentration is one of the strongest indicators of increased risk for coronary heart disease. Apolipoprotein A-I (apo A-I) synthetic defects results in extremely low HDL levels and are frequently although not invariably associated with premature atherosclerosis. To investiga...
Topics
- Animals
- Apolipoprotein A-I
- Apolipoproteins B
- Arteriosclerosis
- Genetic Engineering
- Genotype
- Humans
- Lipoproteins
- Lipoproteins, HDL
- Lipoproteins, LDL
- Mice
- Mice, Knockout
- Mice, Transgenic
- Time Factors