Article
HDL deficiency in genetically engineered mice requires elevated LDL to accelerate atherogenesis.
Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 1997
Hughes S D, Verstuyft J, Rubin E M
Abstract excerpt
In humans, a low HDL concentration is one of the strongest indicators of increased risk for coronary heart disease. Apolipoprotein A-I (apo A-I) synthetic defects results in extremely low HDL levels and are frequently although not invariably associated with premature atherosclerosis. To investigate atherosclerosis susceptibility associated with HDL deficiency alone and in combination with other risk factors, such...
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