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Article

Pathology of atheromatous lesions in inbred and genetically engineered mice. Genetic determination of arterial calcification.

1 Sept 1994

Abstract excerpt

We report comprehensive pathological studies of atheromatous lesions in various inbred mouse strains fed a high-fat, high-cholesterol diet and in two genetically engineered strains that develop spontaneous lesions on a low-fat chow diet. Coronary and aortic lesions were studied with respect to anatomic locations, lesion severity, calcification, and lipofuscin deposition. Surprisingly, the genetic determinants for...

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PMID: 8068611
DOI: 10.1161/01.atv.14.9.1480

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