Article
Evidence for a role of NF-kappaB in the survival of hematopoietic cells mediated by interleukin 3 and the oncogenic TEL/platelet-derived growth factor receptor beta fusion protein.
Proceedings of the National Academy of Sciences of the United States of America - 7 Jul 1998
Besançon F, Atfi A, Gespach C, Cayre Y E, Bourgeade M F
Abstract excerpt
Interleukin 3 (IL-3) and other hematopoietic cytokines transduce signals that stimulate DNA synthesis and cell survival. In certain chronic myelomonocytic leukemias, a TEL/platelet-derived growth factor receptor beta (PDGFRbeta) fusion protein is produced as a consequence of the t(5;12) transloca...
Topics
- Animals
- Apoptosis
- Cell Survival
- DNA-Binding Proteins
- Enzyme Inhibitors
- Hematopoietic Stem Cells
- Interleukin-3
- Mice
- Mutation
- NF-kappa B
- Oncogene Proteins, Fusion
- Proto-Oncogene Proteins c-ets
- Pyridines
- Pyrimidines