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Article

Cellular cofactors affecting hepatitis C virus infection and replication

6 Jul 2007

Abstract excerpt

Recently identified hepatitis C virus (HCV) isolates that are infectious in cell culture provide a genetic system to evaluate the significance of virus-host interactions for HCV replication. We have completed a systematic RNAi screen wherein siRNAs were designed that target 62 host genes encoding proteins that physically interact with HCV RNA or proteins or belong to cellular pathways thought to modulate HCV...

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PMID: 17616579
DOI: 10.1073/pnas.0704894104

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