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Article

Novel therapeutic approach for the treatment of Alzheimer's disease by peripheral administration of agents with an affinity to beta-amyloid.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 1 Jan 2003

Matsuoka Yasuji, Saito Mitsuo, LaFrancois John, Saito Mariko, Gaynor Kate, Olm Vicki, Wang Lili, Casey Evelyn, Lu Yifan, Shiratori Chiharu, Lemere Cynthia, Duff Karen

Abstract excerpt

Plaques containing beta-amyloid (Abeta) peptides are one of the pathological features of Alzheimer's disease, and the reduction of Abeta is considered a primary therapeutic target. Amyloid clearance by anti-Abeta antibodies has been reported after immunization, and recent data have shown that the antibodies may act as a peripheral sink for Abeta, thus altering the periphery/brain dynamics. Here we show that...

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PMID: 12514198
PMCID: PMC6742136

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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