An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

doi:10.1523/JNEUROSCI.4742-11.2012

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Article

An effector-reduced anti-β-amyloid (Aβ) antibody with unique aβ binding properties promotes neuroprotection and glial engulfment of Aβ.

The Journal of neuroscience : the official journal of the Society for Neuroscience - 11 Jul 2012

Adolfsson Oskar, Pihlgren Maria, Toni Nicolas, Varisco Yvan, Buccarello Anna Lucia, Antoniello Katia, Lohmann Sophie, Piorkowska Kasia, Gafner Valerie, Atwal Jasvinder K, Maloney Janice, Chen Mark, Gogineni Alvin, Weimer Robby M, Mortensen Deborah L, Friesenhahn Michel, Ho Carole, Paul Robert, Pfeifer Andrea, Muhs Andreas, Watts Ryan J

Abstract excerpt

Passive immunization against β-amyloid (Aβ) has become an increasingly desirable strategy as a therapeutic treatment for Alzheimer's disease (AD). However, traditional passive immunization approaches carry the risk of Fcγ receptor-mediated overactivation of microglial cells, which may contribute to an inappropriate proinflammatory response leading to vasogenic edema and cerebral microhemorrhage. Here, we describe...

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Identifiers

PMID: 22787053
DOI: 10.1523/JNEUROSCI.4742-11.2012
PMCID: PMC6622286

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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