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A Small Molecule Inhibitor of Plasminogen Activator Inhibitor-1 Reduces Brain Amyloid-β Load and Improves Memory in an Animal Model of Alzheimer's Disease.

Journal of Alzheimer's disease : JAD - 1 Jan 2018

Akhter Hasina, Huang Wen-Tan, van Groen Thomas, Kuo Hui-Chien, Miyata Toshio, Liu Rui-Ming

Abstract excerpt

Alzheimer's disease (AD) is a major cause of dementia in the elderly with no effective treatment. Accumulation of amyloid-β peptide (Aβ) in the brain is a pathological hallmark of AD and is believed to be a central disease-causing and disease-promoting event. In a previous study, we showed that deletion of plasminogen activator inhibitor 1 (PAI-1), a primary inhibitor of tissue type and urokinase type plasminogen...

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PMID: 29914038
DOI: 10.3233/JAD-180241

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