Article
A guanidine-appended scyllo-inositol derivative AAD-66 enhances brain delivery and ameliorates Alzheimer's phenotypes.
Scientific reports - 26 Oct 2017
Lee Dohyun, Lee Woo-Sirl, Lim Sungsu, Kim Yun Kyung, Jung Hoe-Yune, Das Sanket, Lee Juhyun, Luo Wenjie, Kim Kyong-Tai, Chung Sung-Kee
Abstract excerpt
Alzheimer's disease (AD) is a degenerative brain disease that destroys memory and other important mental functions but lacks efficient therapeutic agents. Blocking toxic amyloid β (Aβ) could be beneficial for AD and represents a promising therapeutic strategy for AD treatment. scyllo-Inositol (SI) is a potential therapeutic for AD by directly interacting with the Aβ peptide to inhibit Aβ42 fiber formation....
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