Article
Peritoneal dialysis reduces amyloid-beta plasma levels in humans and attenuates Alzheimer-associated phenotypes in an APP/PS1 mouse model.
Acta neuropathologica - 1 Aug 2017
Jin Wang-Sheng, Shen Lin-Lin, Bu Xian-Le, Zhang Wei-Wei, Chen Si-Han, Huang Zhi-Lin, Xiong Jia-Xiang, Gao Chang-Yue, Dong Zhifang, He Ya-Ni, Hu Zhi-An, Zhou Hua-Dong, Song Weihong, Zhou Xin-Fu, Wang Yi-Zheng, Wang Yan-Jiang
Abstract excerpt
Clearance of amyloid-beta (Aβ) from the brain is an important therapeutic strategy for Alzheimer's disease (AD). Current studies mainly focus on the central approach of Aβ clearance by introducing therapeutic agents into the brain. In a previous study, we found that peripheral tissues and organs play important roles in clearing brain-derived Aβ, suggesting that the peripheral approach of removing Aβ from the...
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