Anti-A 42- and anti-A 40-specific mAbs attenuate amyloid deposition in an Alzheimer disease mouse model

Abstract excerpt

Accumulation and aggregation of amyloid peptide 1-42 (A 42 ) in the brain has been hypothesized as triggering a pathological cascade that causes Alzheimer disease (AD). To determine whether selective targeting of A 42 versus A 40 or total A is an effective way to prevent or treat AD, we compared the effects of passive immunization with an anti-A 42 mAb, an anti-A 40 mAb, and multiple A 1-16 mAbs. We established...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Alzheimer's disease research and treatments
• Share to Cholinesterase and Neurodegenerative Diseases
• Share to Computational Drug Discovery Methods