Article
Analysis of the IgV(H) somatic mutations in splenic marginal zone lymphoma defines a group of unmutated cases with frequent 7q deletion and adverse clinical course.
Blood - 15 Feb 2002
Algara Patricia, Mateo Marisol S, Sanchez-Beato Margarita, Mollejo Manuela, Navas Immaculada C, Romero Lourdes, Solé Francesc, Salido Marta, Florensa Lourdes, Martínez Pedro, Campo Elias, Piris Miguel A
Abstract excerpt
This study aimed to correlate the frequency of somatic mutations in the IgV(H) gene and the use of specific segments in the V(H) repertoire with the clinical and characteristic features of a series of 35 cases of splenic marginal zone lymphoma (SMZL). The cases were studied by seminested polymerase chain reaction by using primers from the FR1 and J(H) region. The results showed unexpected molecular heterogeneity...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.