Article
Homologous recombination as a mechanism of carcinogenesis.
Biochimica et biophysica acta - 21 Mar 2001
Bishop A J, Schiestl R H
Abstract excerpt
Cancer develops when cells no longer follow their normal pattern of controlled growth. In the absence or disregard of such regulation, resulting from changes in their genetic makeup, these errant cells acquire a growth advantage, expanding into pre-cancerous clones. Over the last decade many studies have revealed the relevance of genomic mutation in this process, be it by misreplication, environmental damage or a...
Topics
- Animals
- Carcinogens
- Gene Deletion
- Gene Rearrangement
- Humans
- Loss of Heterozygosity
- Mutation
- Neoplasms
- Oncogenes
- Recombination, Genetic
- Retinal Neoplasms
- Retinoblastoma
- Tumor Cells, Cultured