Loss of heterozygosity induced by a chromosomal double-strand break.

doi:10.1073/pnas.94.17.8988

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Article

Loss of heterozygosity induced by a chromosomal double-strand break.

Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 1997

Moynahan M E, Jasin M

Abstract excerpt

The repair of chromosomal double-strand breaks (DSBs) is necessary for genomic integrity in all organisms. Genetic consequences of misrepair include chromosomal loss, deletion, and duplication resulting in loss of heterozygosity (LOH), a common finding in human solid tumors. Although work with ra...

Topics

Alleles
Animals
Cell Line
DNA Damage
DNA Repair
Genes, Retinoblastoma
Heterozygote
Humans
Mice
Recombination, Genetic

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