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Article

Loss of heterozygosity induced by a chromosomal double-strand break.

Proceedings of the National Academy of Sciences of the United States of America - 19 Aug 1997

Moynahan M E, Jasin M

Abstract excerpt

The repair of chromosomal double-strand breaks (DSBs) is necessary for genomic integrity in all organisms. Genetic consequences of misrepair include chromosomal loss, deletion, and duplication resulting in loss of heterozygosity (LOH), a common finding in human solid tumors. Although work with radiation-sensitive cell lines suggests that mammalian cells primarily rejoin DSBs by nonhomologous mechanisms,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 9256422
DOI: 10.1073/pnas.94.17.8988
PMCID: PMC22995

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