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Article

Carcinogens induce genome-wide loss of heterozygosity in normal stem cells without persistent chromosomal instability.

Proceedings of the National Academy of Sciences of the United States of America - 1 Aug 2006

Donahue Sarah L, Lin Qing, Cao Shang, Ruley H Earl

Abstract excerpt

Widespread losses of heterozygosity (LOH) in human cancer have been thought to result from chromosomal instability caused by mutations affecting DNA repair/genome maintenance. However, the origin of LOH in most tumors is unknown. The present study examined the ability of carcinogenic agents to induce LOH at 53 sites throughout the genome of normal diploid mouse ES cells. Brief exposures to nontoxic levels of...

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Identifiers

PMID: 16868089
DOI: 10.1073/pnas.0510741103
PMCID: PMC1544223

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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