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Article

Evidence for sequential action of two ATPase active sites in yeast Msh2-Msh6.

DNA repair - 4 Sept 2002

Drotschmann Karin, Yang Wei, Kunkel Thomas A

Abstract excerpt

Bacterial MutS homodimers contain two ATPase active sites that have non-equivalent functions in DNA mismatch repair. The homologous Msh2-Msh6 complex in eukaryotes also has intrinsic ATPase activity that is essential for mismatch repair. Here, we investigate differences in the two putative ATPase active sites by examining the properties of heterodimers containing alanine substituted for an invariant glutamic acid...

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Identifiers

PMID: 12509278
DOI: 10.1016/s1568-7864(02)00081-2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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