Article
Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair.
Molecular and cellular biology - 1 Dec 1998
Studamire B, Quach T, Alani E
Abstract excerpt
In the Saccharomyces cerevisiae Msh2p-Msh6p complex, mutations that were predicted to disrupt ATP binding, ATP hydrolysis, or both activities in each subunit were created. Mutations in either subunit resulted in a mismatch repair defect, and overexpression of either mutant subunit in a wild-type strain resulted in a dominant negative phenotype. Msh2p-Msh6p complexes bearing one or both mutant subunits were...
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