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Article

A mutation in the MSH6 subunit of the Saccharomyces cerevisiae MSH2-MSH6 complex disrupts mismatch recognition.

The Journal of biological chemistry - 4 Jun 1999

Bowers J, Sokolsky T, Quach T, Alani E

Abstract excerpt

In yeast, MSH2 interacts with MSH6 to repair base pair mismatches and single nucleotide insertion/deletion mismatches and with MSH3 to recognize small loop insertion/deletion mismatches. We identified a msh6 mutation (msh6-F337A) that when overexpressed in wild type strains conferred a defect in both MSH2-MSH6- and MSH2-MSH3-dependent mismatch repair pathways. Genetic analysis suggested that this phenotype was...

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Share to Adenosine Triphosphatases
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Source

Identifiers

PMID: 10347163
DOI: 10.1074/jbc.274.23.16115

Genes

MSH2
MSH6
MSH3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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A mutation in the MSH6 subunit of the Saccharomyces cerevisiae MSH2-MSH6 complex disrupts mismatch recognition.PMID 10347163Read ↗

Analysis of yeast MSH2-MSH6 suggests that the initiation of mismatch repair can be separated into discrete steps.Semantic proximity Read ↗

Mispair-specific recruitment of the Mlh1-Pms1 complex identifies repair substrates of the Saccharomyces cerevisiae Msh2-Msh3 complex.Semantic proximity Read ↗

Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition.Semantic proximity Read ↗

Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair.Semantic proximity Read ↗

Msh2 separation of function mutations confer defects in the initiation steps of mismatch repair.Semantic proximity Read ↗

Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.Semantic proximity Read ↗

Biochemical basis for dominant mutations in the Saccharomyces cerevisiae MSH6 gene.Semantic proximity Read ↗

Multiple factors insulate Msh2-Msh6 mismatch repair activity from defects in Msh2 domain I.Semantic proximity Read ↗

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Separation-of-function mutations in Saccharomyces cerevisiae MSH2 that confer mismatch repair defects but do not affect nonhomologous-tail removal during recombination.Semantic proximity Read ↗

Requirement of the yeast MSH3 and MSH6 genes for MSH2-dependent genomic stability.Semantic proximity Read ↗

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