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Article

Biochemical basis for dominant mutations in the Saccharomyces cerevisiae MSH6 gene.

Proceedings of the National Academy of Sciences of the United States of America - 17 Jan 2006

Hess Martin T, Mendillo Marc L, Mazur Dan J, Kolodner Richard D

Abstract excerpt

Here, the ATP-binding, ATP hydrolysis, mispair-binding, sliding clamp formation, and Mlh1-Pms1 complex interaction properties of dominant mutant Msh2-Msh6 complexes have been characterized. The results demonstrate two mechanisms for dominance. In one, seen with the Msh6-S1036P and Msh6-G1067D mut...

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Identifiers

PMID: 16407100
DOI: 10.1073/pnas.0510078103
PMCID: PMC1334674

Genes

MSH6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-16407100-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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