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Article

Msh2 separation of function mutations confer defects in the initiation steps of mismatch repair.

Journal of molecular biology - 1 Aug 2003

Kijas Amanda Wraith, Studamire Barbara, Alani Eric

Abstract excerpt

In eukaryotes the MSH2-MSH3 and MSH2-MSH6 heterodimers initiate mismatch repair (MMR) by recognizing and binding to DNA mismatches. The MLH1-PMS1 heterodimer then interacts with the MSH proteins at or near the mismatch site and is thought to act as a mediator to recruit downstream repair proteins. Here we analyzed five msh2 mutants that are functional in removing 3' non-homologous tails during double-strand break...

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Source

Identifiers

PMID: 12875840
DOI: 10.1016/s0022-2836(03)00694-6

Genes

MLH1
MSH2
MSH6
PMS1
MSH3

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Msh2 separation of function mutations confer defects in the initiation steps of mismatch repair.PMID 12875840Read ↗

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