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Article

Conservation of functional asymmetry in the mammalian MutLα ATPase.

DNA repair - 10 Nov 2010

Johnson Jennifer R, Erdeniz Naz, Nguyen Megan, Dudley Sandra, Liskay R Michael

Abstract excerpt

The DNA mismatch repair (MMR) protein dimer MutLα is comprised of the MutL homologues MLH1 and PMS2, which each belong to the family of GHL ATPases. These ATPases undergo functionally important conformational changes, including dimerization of the NH₂-termini associated with ATP binding and hydro...

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Source

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Identifiers

PMID: 20864418
DOI: 10.1016/j.dnarep.2010.08.006
PMCID: PMC2970632

Genes

MLH1
PMS2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-20864418-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

Related research

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