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Article

Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition.

Molecular and cellular biology - 1 May 1997

Alani E, Sokolsky T, Studamire B, Miret J J, Lahue R S

Abstract excerpt

Recent studies have shown that Saccharomyces cerevisiae Msh2p and Msh6p form a complex that specifically binds to DNA containing base pair mismatches. In this study, we performed a genetic and biochemical analysis of the Msh2p-Msh6p complex by introducing point mutations in the ATP binding and pu...

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Identifiers

PMID: 9111312
DOI: 10.1128/MCB.17.5.2436
PMCID: PMC232092

Genes

MSH2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-9111312-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

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Genetic and biochemical analysis of Msh2p-Msh6p: role of ATP hydrolysis and Msh2p-Msh6p subunit interactions in mismatch base pair recognition.PMID 9111312Read ↗

Saccharomyces cerevisiae Msh2p and Msh6p ATPase activities are both required during mismatch repair.Semantic proximity Read ↗

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Analysis of yeast MSH2-MSH6 suggests that the initiation of mismatch repair can be separated into discrete steps.Semantic proximity Read ↗

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Msh2 separation of function mutations confer defects in the initiation steps of mismatch repair.Semantic proximity Read ↗

Evidence for sequential action of two ATPase active sites in yeast Msh2-Msh6.Semantic proximity Read ↗

Contribution of Msh2 and Msh6 subunits to the asymmetric ATPase and DNA mismatch binding activities of Saccharomyces cerevisiae Msh2-Msh6 mismatch repair protein.Semantic proximity Read ↗

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Mispair-specific recruitment of the Mlh1-Pms1 complex identifies repair substrates of the Saccharomyces cerevisiae Msh2-Msh3 complex.Semantic proximity Read ↗

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Redundancy of Saccharomyces cerevisiae MSH3 and MSH6 in MSH2-dependent mismatch repair.Semantic proximity Read ↗

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